Anti-inflammatory Effects of Northern Highbush Blueberry Extract on an In Vitro Inflammatory Bowel Disease Model

Kyle Driscoll, Aparna Deshpande, Rupali Datta, Wusirika Ramakrishna
Nutr Cancer . 2020;72(7):1178-1190.

Blueberry anthocyanins have the ability to efficiently reach the GI tract and exhibit a broad range of biochemical effects. In the context of inflammatory bowel disease (IBD), they remain a promising complement to current IBD treatments. Here, we investigated the anti-inflammatory and antioxidant capabilities of Highbush blueberries in-vitro on two normal colon epithelial cell lines, NCM 356 and CCD 841 CoN using fluorescent microscopy and flow cytometry following stimulation with a pro-inflammatory cytokine cocktail. Treatment with blueberry extract revealed a significant decrease in nuclear and cytoplasmic generated reactive oxygen species (ROS) compared to controls. Additionally, the blueberry extract increased cell viability following treatment with the pro-inflammatory cytokine cocktail. A comparison with previous report on rice callus suspension culture (RCSC) revealed opposing trend with reference to the levels of nuclear and cytoplasmic ROS. It is likely that blueberry extract and RCSC employ different players and pathways to mitigate inflammation.

Latest Inflammation


The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro

Grant A Rutledge, Derek R Fisher, Marshall G Miller, Megan E Kelly, Donna F Bielinski, Barbara Shukitt-Hale
Food Funct . 2019 Dec 11;10(12):7707-7713.
Read More

Blueberries Improve Pain, Gait Performance, and Inflammation in Individuals with Symptomatic Knee Osteoarthritis

Chen Du, Amy Smith, Marco Avalos, Sanique South, Keith Crabtree, Wanyi Wang, Young-Hoo Kwon, Parakat Vijayagopal, Shanil Juma
Nutrients . 2019 Jan 29;11(2):290.
Read More