Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin

H Lamdan, R S Garcia-Lazaro, N Lorenzo, L G Caligiuri, D F Alonso, H G Farina
Exp Oncol . 2020 Jun;42(2):101-108.

Background: Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties.

Aim: In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin.

Materials and methods: A blueberry extract was produced using ethanol as extracting solvent. The anti-proliferative activity of the extract was evaluated against seven tumor cell lines. The properties of blueberry extract to decrease cell adhesion and migration were also investigated.

Results: Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells.

Conclusion: This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro.

Latest Cancer

Postdiagnostic Fruit and Vegetable Consumption and Breast Cancer Survival: Prospective Analyses in the Nurses’ Health Studies

Maryam S Farvid, Michelle D Holmes, Wendy Y Chen, Bernard A Rosner, Rulla M Tamimi, Walter C Willett, A Heather Eliassen
Cancer Res . 2020 Nov 15;80(22):5134-5143.
Read More

Beyond Conventional Medicine – a Look at Blueberry, a Cancer-Fighting Superfruit

Kristoffer T Davidson, Ziwen Zhu, Dean Balabanov, Lei Zhao, Mark R Wakefield, Qian Bai, Yujiang Fang
Pathol Oncol Res . 2018 Oct;24(4):733-738.
Read More

Blueberry and malvidin inhibit cell cycle progression and induce mitochondrial-mediated apoptosis by abrogating the JAK/STAT-3 signalling pathway

Abdul Basit Baba, Ramesh Nivetha, Indranil Chattopadhyay, Siddavaram Nagini
Food Chem Toxicol . 2017 Nov;109(Pt 1):534-543.
Read More