Impact of blueberry consumption on the human fecal bileacidome: A pilot study of bile acid modulation by freeze-dried blueberry. 

William Gagnon, Véronique Garneau, Jocelyn Trottier, Mélanie Verreault, Charles Couillard, Denis Roy, André Marette, Jean-Philippe Drouin-Chartier, Marie-Claude Vohl, Olivier Barbier
Nutrients. 2022; 14(18):3857.

Abstract: Cholesterol-derived bile acids (BAs) affect numerous physiological functions such as glucose homeostasis, lipid metabolism and absorption, intestinal inflammation and immunity, as well as intestinal microbiota diversity. Diet influences the composition of the BA pool. In the present study, we analyzed the impact of a dietary supplementation with a freeze-dried blueberry powder (BBP) on the fecal BA pool composition. The diet of 11 men and 13 women at risk of metabolic syndrome was supplemented with 50 g/day of BBP for 8 weeks, and feces were harvested before (pre) and after (post) BBP consumption. BAs were profiled using liquid chromatography coupled with tandem mass spectrometry. No significant changes in total BAs were detected when comparing pre- vs. post-BBP consumption samples. However, post-BBP consumption samples exhibited significant accumulations of glycine-conjugated BAs (p = 0.04), glycochenodeoxycholic (p = 0.01), and glycoursodeoxycholic (p = 0.01) acids, as well as a significant reduction (p = 0.03) in the secondary BA levels compared with pre-BBP feces. In conclusion, the fecal bileacidome is significantly altered after the consumption of BBP for 8 weeks. While additional studies are needed to fully understand the underlying mechanisms and physiological implications of these changes, our data suggest that the consumption of blueberries can modulate toxic BA elimination.

Latest Gut Health


Scientific Evidence for the Beneficial Effects of Dietary Blueberries on Gut Health: A Systematic Review

Della Lucia CM, Oliveira LA, Dias KA, Pereira SMS, da Conceicao AR, Anandh Babu PV.
Read More

Blueberries Improve Abdominal Symptoms, Well-Being and Functioning in Patients with Functional Gastrointestinal Disorders

Wilder-Smith CH, Materna A, Olesen SS
Nutrients. 2023 May 20;15(10):2396. doi: 10.3390/nu15102396.
Read More

Lactobacillus johnsonii N6.2 and Blueberry Phytophenols Affect Lipidome and Gut Microbiota Composition of Rats Under High-Fat Diet

Leandro Dias Teixeira, Monica F Torrez Lamberti, Evon DeBose-Scarlett, Erol Bahadiroglu, Timothy J Garrett, Christopher L Gardner, Julie L Meyer, Graciela L Lorca, Claudio F Gonzalez
Front Nutr . 2021 Oct 14;8:757256. doi: 10.3389/fnut.2021.757256.
Read More