Physiological Concentrations of Blueberry-Derived Phenolic Acids Reduce Monocyte Adhesion to Human Endothelial Cells

Jeffry S Tang, Stephanie M Bozonet, Judith L McKenzie, Robert F Anderson, Laurence D Melton, Margreet C M Vissers
Mol Nutr Food Res . 2019 Sep;63(18):e1900478.

Scope: Blueberry polyphenols are thought to confer cardiovascular health benefits, but have limited bioavailability. They undergo extensive metabolism and their phenolic acid metabolites are likely to be the mediators of bioactivity. The effect of blueberry-derived phenolic acids on one aspect of inflammation, monocyte adhesion to vascular endothelial cells, is investigated.

Methods and results: The major blueberry-derived phenolic acids in human plasma are identified and quantified. Three test mixtures representing compounds present at 0-4 h (Early), 4-24 h (Late), or 0-24 h (Whole) are used to investigate the effect on adhesion of monocytes to tumor necrosis factor alpha (TNFα)-activated endothelial cells. The Late mixture reduces monocyte adhesion, but there is no effect of the Early or Whole mixtures. Exclusion of syringic acid from each mixture results in inhibition of monocyte adhesion. Exposure to the phenolic acid mixtures has no effect on the endothelial surface expression of adhesion molecules intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), or E-selectin, suggesting that other molecular mechanisms are responsible for the observed effect.

Conclusion: This study shows that physiological concentrations of blueberry polyphenol metabolites can help maintain cardiovascular health by regulating monocyte adhesion to the vascular endothelium.

Latest Cardiovascular & Lipids


Blueberry anthocyanin intake attenuates the postprandial cardiometabolic effect of an energy-dense food challenge: results from a double blind, randomized controlled trial in metabolic syndrome participants

Peter J Curtis, Lindsey Berends, Vera van der Velpen, Amy Jennings, Laura Haag, Preeti Chandra, Colin D Kay, Eric B Rimm, Aedín Cassidy
Clin Nutr. 2022 Jan 1;41(1):165-176.
Read More

Blueberries and cardiovascular disease prevention

Eleanor Wood, Sabine Hein, Christian Heiss, Claire Williams, Ana Rodriguez-Mateos
Food Funct . 2019 Dec 11;10(12):7621-7633.
Read More

Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial

Peter J Curtis, Vera van der Velpen, Lindsey Berends, Amy Jennings, Martin Feelisch, A Margot Umpleby, Mark Evans, Bernadette O Fernandez, Mia S Meiss, Magdalena Minnion, John Potter, Anne-Marie Minihane, Colin D Kay, Eric B Rimm, Aedín Cassidy
Am J Clin Nutr . 2019 Jun 1;109(6):1535-1545.
Read More