Hyperoxia-induced changes in antioxidant capacity and the effect of dietary antioxidants

G Cao, B Shukitt-Hale, P C Bickford, J A Joseph, J McEwen, R L Prior
J Appl Physiol (1985) . 1999 Jun;86(6):1817-22.

We investigated, by measuring oxygen radical absorbance capacity (ORAC), whether hyperoxia causes alterations in antioxidant status and whether these alterations could be modulated by dietary antioxidants. Rats were fed for 8 wk a control diet or a control diet supplemented with vitamin E (500 IU/kg) or with aqueous extracts (ORAC: 1.36 mmol Trolox equivalents/kg) from blueberries or spinach and then were exposed to air or >99% O2 for 48 h. Although the constituents of the extracts were not extensively characterized, HPLC indicated that blueberry extract was particularly rich in anthocyanins, and the spinach extract did not contain any anthocyanins. The ORAC was determined in samples without proteins [serum treated with perchloric acid (PCA); ORACPCA] and with proteins (ORACtot). Hyperoxia induced a decrease in serum protein concentration, an increase in serum ORACPCA, decreases in lung ORACPCA and ORACtot, and an equilibration of proteins and ORACPCA between serum and pleural effusion. These alterations suggested a redistribution of antioxidants between tissues and an increase in capillary permeability during hyperoxia. Only the blueberry extract was effective in alleviating the hyperoxia-induced redistribution of antioxidants between tissues.

Latest Antioxidant Activity


Phenolic compounds of blueberries ( Vaccinium spp) as a protective strategy against skin cell damage induced by ROS: A review of antioxidant potential and antiproliferative capacity

Daniela A Maya-Cano, Sandra Arango-Varela, Gloria A Santa-Gonzalez
Heliyon. 2021 Feb 17;7(2):e06297.
Read More

Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings

Luyao Ma, Zhenghai Sun, Yawen Zeng, Mingcan Luo, Jiazhen Yang
Int J Mol Sci . 2018 Sep 16;19(9):2785. doi: 10.3390/ijms19092785.
Read More

Blueberry supplementation attenuates oxidative stress within monocytes and modulates immune cell levels in adults with metabolic syndrome: a randomized, double-blind, placebo-controlled trial

Anand R Nair, Nithya Mariappan, April J Stull, Joseph Francis
Food Funct . 2017 Nov 15;8(11):4118-4128.
Read More