Scientific Research

The U.S. Highbush Blueberry Council (USHBC) funds research studies that are grounded in sound science, use rigorous methodology, and are conducted by autonomous researchers at well-established institutions. All published research is submitted to peer-reviewed journals by the researcher, independent of the USHBC.

Explore the full overview of research specifically funded by the USHBC, and examine the full body of evidence on blueberry science by browsing the research topics below.

Blueberry Supplementation Effects on Neuronal and Pathological Biomarkers in Subjects at Risk for Alzheimer’s Disease: A Pilot Study

P M Doraiswamy, M G Miller, C A Hellegers, A Nwosu, J Choe, D M Murdoch
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Blueberry benefits to cognitive function across the lifespan

Lynne Bell, Claire M Williams
Int J Food Sci Nutr . 2021 Aug;72(5):650-652. doi: 10.1080/09637486.2020.1852192.
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Effect of blueberry (Vaccinium virgatum) extract on depressive-like behavior and metabolic serum alterations in lipopolysaccharide-challenged mice

Solange Vega Custódio, Luiza Spohr, Natália Pontes Bona, Anita Avila de Souza, Bernardo de Moraes Meine, Sara Keske, Karina Pereira Luduvico, Fernando Lopez Alvez, Roselia Maria Spanevello, Francieli Moro Stefanello, Mayara Sandrielly Pereira Soares
J Food Biochem . 2021 Oct;45(10):e13920. doi: 10.1111/jfbc.13920
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Blueberry Supplementation in Midlife for Dementia Risk Reduction

Robert Krikorian, Matthew R. Skelton, Suzanne S. Summer, Marcelle D. Shidler, Patrick G. Sullivan
Nutrients. 2022 Apr 13; 14(8):1619
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Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study: Rationale, design and baseline characteristics of a randomized control trial of the MIND diet on cognitive decline

Xiaoran Liu, Martha Clare Morris, Klodian Dhana, Jennifer Ventrelle, Kathleen Johnson, Louise Bishop, Chiquia S Hollings, Adrianna Boulin, Nancy Laranjo, Benjamin J Stubbs, Xavier Reilly, Vincent J Carey, Yamin Wang, Jeremy D Furtado, Santica M Marcovina, Christy Tangney, Neelum T Aggarwal, Konstantinos Arfanakis, Frank M Sacks, Lisa L Barnes
Contemp Clin Trials. 2021 Mar;102:106270.
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Blueberry phenolics are associated with cognitive enhancement in supplemented healthy older adults

Rutledge GA, Sandhu AK, Miller MG, Edirisinghe I, Burton-Freeman BB, Shukitt-Hale B.
Food Funct. 2021 Jan 7;12(1):107-118.
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Cognitive performance in relation to urinary anthocyanins and their flavonoid-based products following blueberry supplementation in older adults at risk for dementia.

Krikorian R, Kalt W, McDonald JE, Shidler MD, Summer SS, Stein AL.
Journal of Functional Foods, Volume 64, 2020, 103667, ISSN 1756-4646.
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Digestion behavior and antidepressant-like effect promoted by acute administration of blueberry extract on mice

Andreia Gapski, Trilicia M Gomes, Maiara A Bredun, Nayla E Ferreira-Lima, Fabiana Kalyne Ludka, Marilde T Bordignon-Luiz, Vívian Maria Burin
Food Res Int . 2019 Nov;125:108618.
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Blueberries Improve Neuroinflammation and Cognition differentially Depending on Individual Cognitive baseline Status

Barbara Shukitt-Hale, Nopporn Thangthaeng, Marshall G Miller, Shibu M Poulose, Amanda N Carey, Derek R Fisher
J Gerontol A Biol Sci Med Sci. 2019 Jun 18;74(7):977-983.
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