Scientific Research

The U.S. Highbush Blueberry Council (USHBC) funds research studies that are grounded in sound science, use rigorous methodology, and are conducted by autonomous researchers at well-established institutions. All published research is submitted to peer-reviewed journals by the researcher, independent of the USHBC.

Explore the full overview of research specifically funded by the USHBC, and examine the full body of evidence on blueberry science by browsing the research topics below.

Blueberry antagonism of C-2 ceramide disruption of Ca2+ responses and recovery in MAChR-transfected COS-7 cell

James A Joseph 1, Anna Neuman, Donna F Bielinski, Derek R Fisher
J Alzheimers Dis . 2008 Nov;15(3):429-41.
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Blueberry opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activation protein kinase

Yuyan Zhu, Paula C Bickford, Paul Sanberg, Brian Giunta, Jun Tan
Rejuvenation Res . 2008 Oct;11(5):891-901.
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Beneficial effects of berry fruit polyphenols on neuronal and behavioral aging

Lau, F.C. Search author for Lau, F.C. , Shukitt-Hale, B., Joseph, J.A.
Journal of the science of food and agriculture, v. 86,.14 pp. 2251.
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Blueberry-enriched diet ameliorates age-related declines in NMDA receptor-dependent LTP

Steven J Coultrap, Paula C Bickford, Michael D Browning
Age (Dordr) . 2008 Dec;30(4):263-72.
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Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus

Barbara Shukitt-Hale, Francis C Lau, Amanda N Carey, Rachel L Galli, Edward L Spangler, Donald K Ingram, James A Joseph
Nutr Neurosci . 2008 Aug;11(4):172-82.
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Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels

Claire M Williams, Manal Abd El Mohsen, David Vauzour, Catarina Rendeiro, Laurie T Butler, Judi A Ellis, Matthew Whiteman, Jeremy P E Spencer
Free Radic Biol Med . 2008 Aug 1;45(3):295-305.
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Berry fruit supplementation and the aging brain

Barbara Shukitt-Hale, Francis C Lau, James A Joseph
J Agric Food Chem . 2008 Feb 13;56(3):636-41.
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Dopamine and Abeta-induced stress signaling and decrements in Ca2+ buffering in primary neonatal hippocampal cells are antagonized by blueberry extract

J A Joseph, A Carey, G J Brewer, F C Lau, D R Fisher
J Alzheimers Dis . 2007 Jul;11(4):433-46.
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A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats

Kara B Duffy, Edward L Spangler, Bryan D Devan, Zhihong Guo, Jonna L Bowker, Anne M Janas, Adrienne Hagepanos, Robin K Minor, Rafael DeCabo, Peter R Mouton, Barbara Shukitt-Hale, James A Joseph, Donald K Ingram
Neurobiol Aging . 2008 Nov;29(11):1680-9.
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