Scientific Research

The U.S. Highbush Blueberry Council (USHBC) funds research studies that are grounded in sound science, use rigorous methodology, and are conducted by autonomous researchers at well-established institutions. All published research is submitted to peer-reviewed journals by the researcher, independent of the USHBC.

Explore the full overview of research specifically funded by the USHBC, and examine the full body of evidence on blueberry science by browsing the research topics below.

Blueberry treatment antagonizes C-2 ceramide-induced stress signaling in muscarinic receptor-transfected COS-7 cells

James A Joseph, Donna F Bielinski, Derek R Fisher
J Agric Food Chem . 2010 Mar 24;58(6):3380-92.
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Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract

Gregory J Brewer, John R Torricelli, Amanda L Lindsey, Elizabeth Z Kunz, A Neuman, Derek R Fisher, James A Joseph
J Nutr Biochem . 2010 Oct;21(10):991-8.
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Beneficial effects of antioxidant-enriched diet for tyrosine hydroxylase-positive neurons in ventral mesencephalic tissue in oculo grafts

Elisabet Berglöf, Brent J Small, Paula C Bickford, Ingrid Strömberg
J Comp Neurol . 2009 Jul 1;515(1):72-82.
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Blueberry antagonism of C-2 ceramide disruption of Ca2+ responses and recovery in MAChR-transfected COS-7 cell

James A Joseph 1, Anna Neuman, Donna F Bielinski, Derek R Fisher
J Alzheimers Dis . 2008 Nov;15(3):429-41.
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Blueberry opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activation protein kinase

Yuyan Zhu, Paula C Bickford, Paul Sanberg, Brian Giunta, Jun Tan
Rejuvenation Res . 2008 Oct;11(5):891-901.
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Beneficial effects of berry fruit polyphenols on neuronal and behavioral aging

Lau, F.C. Search author for Lau, F.C. , Shukitt-Hale, B., Joseph, J.A.
Journal of the science of food and agriculture, v. 86,.14 pp. 2251.
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Blueberry-enriched diet ameliorates age-related declines in NMDA receptor-dependent LTP

Steven J Coultrap, Paula C Bickford, Michael D Browning
Age (Dordr) . 2008 Dec;30(4):263-72.
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Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus

Barbara Shukitt-Hale, Francis C Lau, Amanda N Carey, Rachel L Galli, Edward L Spangler, Donald K Ingram, James A Joseph
Nutr Neurosci . 2008 Aug;11(4):172-82.
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Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels

Claire M Williams, Manal Abd El Mohsen, David Vauzour, Catarina Rendeiro, Laurie T Butler, Judi A Ellis, Matthew Whiteman, Jeremy P E Spencer
Free Radic Biol Med . 2008 Aug 1;45(3):295-305.
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