Scientific Research

The U.S. Highbush Blueberry Council (USHBC) funds research studies that are grounded in sound science, use rigorous methodology, and are conducted by autonomous researchers at well-established institutions. All published research is submitted to peer-reviewed journals by the researcher, independent of the USHBC.

Explore the full overview of research specifically funded by the USHBC, and examine the full body of evidence on blueberry science by browsing the research topics below.

Berry fruit supplementation and the aging brain

Barbara Shukitt-Hale, Francis C Lau, James A Joseph
J Agric Food Chem . 2008 Feb 13;56(3):636-41.
Read More

Dopamine and Abeta-induced stress signaling and decrements in Ca2+ buffering in primary neonatal hippocampal cells are antagonized by blueberry extract

J A Joseph, A Carey, G J Brewer, F C Lau, D R Fisher
J Alzheimers Dis . 2007 Jul;11(4):433-46.
Read More

A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats

Kara B Duffy, Edward L Spangler, Bryan D Devan, Zhihong Guo, Jonna L Bowker, Anne M Janas, Adrienne Hagepanos, Robin K Minor, Rafael DeCabo, Peter R Mouton, Barbara Shukitt-Hale, James A Joseph, Donald K Ingram
Neurobiol Aging . 2008 Nov;29(11):1680-9.
Read More

Fruit polyphenols and their effects on neuronal signaling and behavior in senescence

James A Joseph, Barbara Shukitt-Hale, Francis C Lau
Ann N Y Acad Sci . 2007 Apr;1100:470-85.
Read More

Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microglia

Francis C Lau, Donna F Bielinski, James A Joseph
J Neurosci Res . 2007 Apr;85(5):1010-7.
Read More

Dopamine-induced stress signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes is partially mediated via the i3 loop and antagonized by blueberry extract

J A Joseph, D R Fisher, A N Carey, D F Bielinski
J Alzheimers Dis . 2006 Dec;10(4):423-37.
Read More

Dietary supplementation with blueberry extract improves survival of transplanted dopamine neurons

Susan O McGuire, Caryl E Sortwell, Barbara Shukitt-Hale, James A Joseph, Matthew J Hejna, Timothy J Collier
Nutr Neurosci. 2006 Oct-Dec;9(5-6):251-8.
Read More

Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity

Yu Yao, Amandio Vieira
Neurotoxicology . 2007 Jan;28(1):93-100.
Read More

Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging

Barbara Shukitt-Hale, Amanda N Carey, Daniel Jenkins, Bernard M Rabin, James A Joseph
Neurobiol Aging . 2007 Aug;28(8):1187-94.
Read More