Scientific Research

The U.S. Highbush Blueberry Council (USHBC) funds research studies that are grounded in sound science, use rigorous methodology, and are conducted by autonomous researchers at well-established institutions. All published research is submitted to peer-reviewed journals by the researcher, independent of the USHBC.

Explore the full overview of research specifically funded by the USHBC, and examine the full body of evidence on blueberry science by browsing the research topics below.

Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory

Cristina Andres-Lacueva, Barbara Shukitt-Hale, Rachel L Galli, Olga Jauregui, Rosa M Lamuela-Raventos, James A Joseph
Nutr Neurosci . 2005 Apr;8(2):111-20.
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Blueberry extract enhances survival of intraocular hippocampal transplants

Lauren Willis, Paula Bickford, Vandana Zaman, Alfred Moore, Ann-Charlotte Granholm
Cell Transplant . 2005;14(4):213-23. doi: 10.3727/000000005783983142.
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Dietary supplementation with blueberries, spinach, or spirulina reduces ischemic brain damage

Yun Wang, Chen-Fu Chang, Jenny Chou, Hui-Ling Chen, Xiaolin Deng, Brandon K Harvey, Jean Lud Cadet, Paula C Bickford
Exp Neurol . 2005 May;193(1):75-84.
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Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds

James A Joseph, Barbara Shukitt-Hale, Gemma Casadesus
Am J Clin Nutr . 2005 Jan;81(1 Suppl):313S-316S.
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Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats

Gemma Casadesus, Barbara Shukitt-Hale, Heather M Stellwagen, Xiongwei Zhu, Hyoung-Gon Lee, Mark A Smith, James A Joseph
Nutr Neurosci . Oct-Dec 2004;7(5-6):309-16.
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Blueberry supplemented diet: effects on object recognition memory and nuclear factor-kappa B levels in aged rats

Pilar Goyarzu, David H Malin, Francis C Lau, Giulio Taglialatela, William D Moon, Ryan Jennings, Edward Moy, Deborah Moy, Stephen Lippold, Barbara Shukitt-Hale, James A Joseph
Nutr Neurosci . 2004 Apr;7(2):75-83.
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Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model

J A Joseph, N A Denisova, G Arendash, M Gordon, D Diamond, B Shukitt-Hale, D Morgan
Nutr Neurosci . 2003 Jun;6(3):153-62.
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Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats

P C Bickford, T Gould, L Briederick, K Chadman, A Pollock, D Young, B Shukitt-Hale, J Joseph
Brain Res . 2000 Jun 2;866(1-2):211-7.
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Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation

J A Joseph, B Shukitt-Hale, N A Denisova, D Bielinski, A Martin, J J McEwen, P C Bickford
J Neurosci . 1999 Sep 15;19(18):8114-21.
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